Normally, Polycystic Kidney Disease patients feel no obvious symptoms at the early stage of Polycystic Kidney Disease when the cysts are still very small. However, due to gene factor, cysts are enlarging all the time and as a result, related symptoms will appear gradually.
High Blood Pressure is the first symptom that happens. With cysts enlarging, they will compress surrounding kidney tissue as well as surrounding blood vessel, causing local renal ischemia which can induce more rennin secretion. As a result, the concentration of angiotensin increases. At the same time, blood vessels become narrower, and then blood pressure increases. What’s worse, high blood pressure will also speed up the progress of kidney function decline.
Pain on unilateral or bilateral kidney region is also commonly felt by polycystic kidney disease patients. Cysts enlargement can cause power to pull surrounding kidney tissue and renal vascular pedicle, which can make patients feel painful. Besides, if polycystic kidney disease is complicated with infection, obstruction or stones, painful feeling will be more serious.
Haematuria is another common symptom of polycystic kidney disease. When cysts enlarge to a certain degree, cyst rupture is easy to happen and then haematuria occurs. Besides, polycystic kidney disease patients always have lower immunity than healthy people, so they are also easier to get infection on cysts or urinary tract, which is also a main reason of haematuria.
Polycystic pathological change on other internal organs is also usually found, such as cysts in liver, pancreas, spleen, and so on. Presently, no exact reason is found to explain this symptom. However, with polycystic kidney disease being treated effectively, cysts in other organs will also be relieved.
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