According to ISN/RPS, Lupus Nephritis can be divided into the following types
roughly. And, there are also many further classifications of lupus nephritis,
but I did not mentioned here.
Class I. Minimal mesangial lupus nephritis: normal glomeruli under light microscope, but with minimal mesangial deposits in immunofluorescence.
Class II. Proliferative mesangial lupus nephritis: hypercellularity and mild mesangial expansion under light microscope, with mesangial deposits evident
in immunofluorescence; there may be subepithelial or subendothelial deposits visible in an electron microscope or with immunofluorescence.
Class III. Focal lupus nephritis: lesions present in <50% of glomeruli with endo or extracapillary lesions, subendothelial deposits, with or without mesangial involvement. There may be active (A) or chronic (C) lesions, leading to the subdivision into:
- Class III (A): active lesions (focal proliferative lupus nephritis)
- Class III (A/C): active and chronic lesions (focal and sclerosing proliferative lupus nephritis)
- Class III (C): inactive chronic scarring lesions (focal sclerosing lupus nephritis)
Class IV. Diffuse lupus nephritis:lesions in >_50% of glomeruli with diffuse subendothelial deposits, with or without mesangial alterations. May have A or C lesions. In addition, the lesions may be segmental or global.
Class I. Minimal mesangial lupus nephritis: normal glomeruli under light microscope, but with minimal mesangial deposits in immunofluorescence.
Class II. Proliferative mesangial lupus nephritis: hypercellularity and mild mesangial expansion under light microscope, with mesangial deposits evident
in immunofluorescence; there may be subepithelial or subendothelial deposits visible in an electron microscope or with immunofluorescence.
Class III. Focal lupus nephritis: lesions present in <50% of glomeruli with endo or extracapillary lesions, subendothelial deposits, with or without mesangial involvement. There may be active (A) or chronic (C) lesions, leading to the subdivision into:
- Class III (A): active lesions (focal proliferative lupus nephritis)
- Class III (A/C): active and chronic lesions (focal and sclerosing proliferative lupus nephritis)
- Class III (C): inactive chronic scarring lesions (focal sclerosing lupus nephritis)
Class IV. Diffuse lupus nephritis:lesions in >_50% of glomeruli with diffuse subendothelial deposits, with or without mesangial alterations. May have A or C lesions. In addition, the lesions may be segmental or global.
