Thursday, 15 March 2012

A New Breakthrough, Immunotherapy, for Kidney Disease

In order to treat Kidney Disease more effectively, the cause of kidney disease is the first thing that should be known clearly. According to the latest research, the most basic cause of kidney disease is the abnormality of inherent immune system and backup immune system. Once both inherent immune system and backup immune system can now work normally, immune complex in body will not be able to be discharged out of body. What’s more, immune complex deposit in body can reach to kidney with blood circulation and then deposite in kidney because the surface of immune complex is suitable to the renal binding epitopes, thus accumulating to kidney tissue and causing damage to kidney gradually. When the damage in kidney progresses into a certain degree, a series of symptoms occur.
From the above, it is clear that only controlling the symptoms and removing the immune complex in kidney is not enough to treat kidney disease. The disease will be easily to reoccur even though the treatment effect is very good in a short period because immune complex will deposite in kidney again due to abnormal immune system function, which is also the basic reason why kidney disease is difficult to be treated and is easy to get relapse. Therefore, the most effective method to treat kidney disease should not only remove the immune complex in body, but also repair the abnormal immune system. Only in this way, kidney disease can be treated more effectively and there will be less relapse. Based on this condition, immunotherapy was researched out and applied in treating kidney disease.
Normally, immunotherapy can be divided into two main parts in treating kidney disease.
First is exact diagnosis. No medicine can be offered before making the correct diagnosis. At present, only a few testing methods are used to check kidney disease. If medicine is prescribed before exact diagnosis, the treatment will not be so targeted and as a result, the effect can also be not as good as we expected. Only offering treatment or medicine by experience will make patients cost more money and time. This may also make patients condition getting worse finally. Therefore, exact diagnosis is the most important and basic step during the treatment. Here the diagnosis not only referes to the kidney disorder, but also the immune system, such as the damage degree of immune system, the deposit position of immune complex and the damage degree caused by the immune complex, etc. Only by exact diagnosis, the treatment can be more targeted and the treatment effect can be much better.
The second part is some treatment methods in the whole immunotherapy, which includes immune blocking, immune tolerance, immune adjustment, immune protection as well as immune clearance.
The treatment for kidney disease should be comprehensive and systematic in order to get better effect. Therefore, the treatment methods that are needed in the whole immunotherapy procedure are cooperating and supporting each other mutually.
When immune complex deposite in kidney abnormally, it will cause damage to kidney, so the first thing should be done is to use some immunosuppressant to stop and block the further damage to kidney caused by immune complex.
After this, even though immune complex will not do harms to kidney, but the former deposited immune complex is still in kidney, so the next step is to make the kidney to become adaptive to the immune complex, which is called immune tolerance. Once kidney adapts the immune complex and the damaged condition caused by the immune complex, it will not mediate the inflammation reaction to the immune complex, which can avoid further damage in kidney caused by the inflammation reaction.
Immune adjustment is offered after immune tolerance in order to recover immune system to normal level, so immune complex will not appear again. By improving immune system, the ability of removing infectious agent of human body will also be improved at the same time.
The importance of immune protection is to prevent kidney disease progressing further after being controlled well. This needs patient have regular check on their body condition in order to take suppressant medicine according to patient individual illness condition. The main aim in this stage is to protect inherent renal cells and kidney tissue by inhibiting the abnormal immune reaction.
Immune clearance is to remove and eliminate the immune complex in body via immune clearance ability, which can prevent the illness condition aggravation and relapse effectively.
Normally, in treating kidney disease, medications to control symptoms and repair damaged kidney tissue and cells are necessary, but it is not enough. The most basic treatment should be started with recovering the immune system. Only immune system becomes normal, kidney disease can be treated more fundamentally.

1 comment:

  1. Bella, thank you for your info about immunotherapy, it is really helpful!

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