We all know IgA Nephropathy is a kind of immune system disease. Here, I attached a picture, which may make it more clear.
We know that IgA Nephropathy is caused by inflammation reaction in kidney due to immune complex IgA deposit in mesangial area. Thus mesangial cells will be damaged first. With more and more IgA deposit, pathological damage will certainly happen in mesangial area. Mesangial area has the function of adjusting blood pressure, so IgA Nephropathy patients will have high blood pressure with the progression of the disease gradually. With the disease progressing, the pathological damage will also involves to the endothelial cells and basement membrane. Basement membrane has the filtrating function. When filtrating function declines more, protein leaks out with urine. Actually, the more protein in urine, the more serious damage in basement membrane. Besides, according to the research, the prognosis is more serious if patients protein in urine can not be treated well.
From the above, we should also begin to know how the treatment is taken.
Firstly, the inflammation should be stopped first so as to prevent more damage in mesangial area. In most hospitals or countries, hormones or immune suppressant are suggested. However, these medicine can not only inhibit the abnormal immune reaction in kidney, but also inhibit the whole body immunity, which makes people have lower immunity. Therefore, the side effects is also a great problem.
Then, after stop inflammation reaction, the deposit immune complex should also be removed and in this way, there is no new inflammation anymore. Of course, the existed damage in mesangial area should also be repaired. Then, the disease can be controlled well. At the same time, using treatment to adjust patient whole body immunity. To be honest, a systematic treatment should contain the above points. However, most doctors only keep their treatment or medications at the first step, which is the main reason of the disease relapse.
Besides, due to low immunity, IgA Nephropathy patients are also easy to get low immunity, which makes them are easy to get various infection. Thefore, preventing infection is very important.
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